Abstract
Fenbufen, a member of nonsteroidal antiinflammatory drugs and widely used in the treatment of rheumatoid arthritis was imprinted by utilizing a zwitterionic polymeric format, N-[(phenylenediammonium) maleimidopropane sulfonate] copolymer. Imprinting was carried out by grafting polymer on a photoiniferter modified silica gel via living radical polymerization. Electrostatic interactions along with complementary H-bonding and other hydrophobic interactions inducing additional synergetic effect between the template (fenbufen) and the imprinted surface led to the formation of imprinted sites. Grafted molecularly imprinted polymer (MIP) was characterized by FTIR and surface area measurements besides the recognition, rebinding and selectivity studies. The surface area, pore diameter and pore volume of the MIP are 259.06 m2/g, 4.99 nm and 0.32 cm3/g, respectively. The MIP was able to selectively and specifically take up fenbufen quantitatively. Hence, a facile, specific and selective technique using surface-grafted specific molecular contours developed for specific and selective uptake of fenbufen in the presence of various interferrants, in different kinds of matrices is presented.
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