Abstract
CHF 2OCH 3 (HFE-152a), an important starting material for synthesizing various C 2 hydrofluoroethers and a prospective alternative to CH 3CF 2Cl (HCFC-142b), has been found to be effectively produced from the reaction of CHF 2Cl (HCFC-22) with alkali metal carbonates in methanol. Some alkali metal carbonates induce selective production of CHF 2OCH 3 with a small amount of CH(OCH 3) 3, a major side product. Activities of alkali metal carbonates for producing CHF 2OCH 3 are in the order of K 2CO 3>Na 2CO 3>Li 2CO 3, suggesting that the solubility and ionization tendency of alkali metal carbonate in methanol play important roles in the reaction.
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