Abstract
A new and rapid potentiometric method for determination of flucloxacillin is developed. The method involves development of a flucloxacillin sensor with a membrane consisting of Aliquat 336S-flucloxacillin as an electroactive material in poly vinyl chloride matrix membrane plasticized with orthonitrophenyl-octylether or dioctylphthalate. The sensor shows fast, stable and reproducible response over the concentration range of 1.0×10−5–1.0×10−2M flucloxacillin with anionic slopes of 60.7±0.3 and 61.2±0.2 and pH ranges of 6–11 and 7–11 for o-nitrophenyloctylether (o-NPOE) and dioctylphthalate (DOP) plasticized based membrane sensors, respectively. The response time of the sensor is stable and fast (7s). The sensor exhibits high selectivity towards flucloxacillin in presence of amoxicillin, ampicillin, dicluxacillin, pencillin, many anions and drug excipients and diluents. Validation of the method according to the quality assurance standards shows suitability of the proposed sensors for use in the quality control assessment of the drug. Results with average recoveries of 99.6% and 99.7% and mean standard deviations of ±1.2% and ±1.5% for o-NPOE and DOP plasticized based membrane sensors, respectively, of the nominal are obtained which compare fairly well with data obtained using the British Pharmacopoeia method.
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