Abstract
Phosphodiesterase 4B (PDE4B) is a member of the phosphodiesterase family of proteins that plays a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) by controlling its rate of degradation. It has been demonstrated that this isoform is involved in the orchestra of events which includes inflammation, schizophrenia, cancers, chronic obstructive pulmonary disease, contractility of the myocardium, and psoriatic arthritis. Phosphodiesterase 4B has constituted an interesting target for drug development. In recent years, a number of PDE4B inhibitors have been developed for their use as therapeutic agents. In this review, an up-to-date status of the inhibitors investigated for the inhibition of PDE4B has been given so that this rich source of structural information of presently known PDE4B inhibitors could be helpful in generating a selective and potent inhibitor of PDE4B.
Highlights
Phosphodiesterases (PDEs) are a diverse family of enzymes involved in phosphoric diester hydrolytic cleavage
Cyclic nucleotide PDEs constitute a superfamily of enzymes which catalyze the hydrolysis of 3',5'-cyclic adenosine monophosphate and 3',5'-cyclic guanosine monophosphate to their inactive 5′-AMP and 5’-GMP forms, respectively
We present the most significant examples of Phosphodiesterase 4B (PDE4B) inhibitors that exhibit various biological activities reported in literature
Summary
Department of Pharmaceutical Chemistry, J. S. S. College of Pharmacy, Ootacamund-643001, Tamil Nadu, India. © Azam and Tripuraneni; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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