Abstract
Regional and intrabronchial particle deposition patterns determined in experimental inhalation tests using a hollow cast of the human tracheobronchial tree, γ-tagged aerosols, and a collimated radiation detector were compared to the distribution of sites of origin of primary bronchogenic tumors in the upper bronchial tree obtained from available published reports. A close correspondence between relative deposition efficiency and frequency of reported cancer at those sites suggests that the deposition characteristics of the airways may play a significant role in cancer pathogenesis.
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