Abstract

A new and selective palladium-catalyzed amination of the pyrido[3′,3′:4,5]pyrrolo[1,2- c]pyrimidine nucleus, the heterocyclic core of the variolin alkaloids, is described. The method allows the introduction of amino and aryl- and alkylamino substituents on the C9 position in advanced precursors of variolin B and deoxyvariolin.

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