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Abstract
5-(Hydroxymethyl)furfural is readily oxidized to furan-2,5-dicarbaldehyde with sodium nitrite in phosphoric acid at room temperature (25°C). The best selectivity for furan-2,5-dicarbaldehyde is achieved using 2.5 equiv of sodium nitrite with respect to the substrate. In this case, nearly quantitative yield of furan- 2,5-dicarbaldehyde is attained in 1 h, the substrate conversion being complete. Due to high selectivity in combination with low cost and toxicity of phosphoric acid, the system NaNO2–H3PO4 is more convenient than NaNO2–CF3COOH for the preparative synthesis of furan-2,5-dicarbaldehyde.
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