Abstract
We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes. This mild and operationally simple protocol is distinguished by its broad substrate scope and excellent chemo-, regio-, and stereo-selectivity, offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs. Preliminary mechanistic studies have been conducted to probe the potential reaction pathway.
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