Abstract
The use of <i>N</i>,<i>N</i>-dimethylformamide dimethylacetal (DMF-DMA) as a suitable methylating agent for the methylation of NH-containing groups and heterocycles has been investigated. Use of ReactArray and calculated p<i>K</i> <sub>a</sub> measurements have allowed additional helpful information to be collated to determine optimum reaction conditions for a variety of substrates.
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