Selective laser welding in liquid: A strategy for preparation of high-antibacterial activity nanozyme against Staphylococcus aureus

Abstract

Nanozyme was considered as one of the most promising substitutes for antibiotics, due to the selective catalysis for pathogens. In this work, a high-antibacterial activity SOD-like nanozyme based on hybrid Ag/CeO2 nanocomposite was facilely prepared by using an innovative approach of selective laser welding in liquid. This prepared nanozyme displayed a high antimicrobial effect against Staphylococcus aureus under visible light illumination, the sterilization rate as high as 82.4%, which was 2.93 and 2.99 times higher than those of pure Ag and pure CeO2, respectively. The enhanced antibacterial activity was attributed to the anchoring of Ag nanospheres on the surface of CeO2 nanosheets, which induced the reduction of CeO2 bandgap and boosted the visible light harvesting. Therefore, the charge carriers can be effectively stimulated to produce abundant reactive oxygen species on the Ag/CeO2 nanocomposite via a SOD-like route. This work demonstrated a facile strategy for the preparation of high-antibacterial activity nanozyme, giving it great potential for scalable application in the biomedical and pharmaceutical industry.