Abstract
6-methylpurine 2′-deoxyriboside killed mouse macrophages infected with amastigotes of Leishmania donovani and Leishmania mexicana , but did not affect the growth of non-parasitized cells. Leishmania extracts cleaved the non-toxic 6-methylpurine 2′-deoxyriboside to 6-methylpurine, a potent adenine antimetabolite for mammalian cells. By eliminating macrophages latently infected with Leishmania donovani amastigotes, 6-methylpurine 2′-deoxyriboside could augment the effects of leishmanicidal agents in vivo .
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