Abstract
The effects of various flavonoids on platelet lipoxygenase and cyclooxygenase activities were studied. Baicalein selectively inhibited platelet lipoxygenase. The concentration for 50% inhibition (ID 50) was 0.12 μM for platelet lipoxygenase and 0.83 mM for platelet cyclooxygenase. Therefore, the ID 50 value for the cyclooxygenase was 6917 times that for the lipoxygenase. Baicalin also selectively inhibited the lipoxygenase, but it was less potent (ID 50=100 μM). Other flavonoids tested had no inhibitory effect on either enzyme.
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