Selective inhibition of liver-cell proliferation by CFT 1201 and SKF 525 A. Studies on growth processes induced by drugs and by partial hepatectomy.

Abstract

Of the xenobiotic compounds which are known to induce liver growth some are substrates of hepatic microsomal mixed-function oxidase. The aim of the present study was to check on whether normal functioning of this enzyme system is a prerequisite for growth induction by α-HCH***, BHT, and phenobarbital. Several biochemical and morphological tests were used to determine the degree of hyperplasia and hypertrophy induced in rat liver by these drugs, with and without concomitant application of two inhibitors of microsomal mixed-function oxidase: SKF 525 A and CFT 1201.