Abstract
The oxygen gradient across the liver lobule was measured in isolated, hemoglobin-free perfused livers from control and ethanol-treated rats using micro-light guides and miniature oxygen electrodes. Both techniques yielded similar values for the lobular, periportal and pericentral oxygen gradients. Oxygen uptake increased 33% in livers from rats treated with ethanol for 4 to 6 weeks. In addition, the pericentral oxygen gradient increased by 100%, but the periportal gradient was unchanged. These observations suggest that chronic ethanol treatment may increase the rate of cellular respiration in ethanol-induced inhibition of glycolysis which predominates in pericentral hepatocytes.
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