Abstract
Summary. A specific lactate dehydrogenase inhibitor, sodium oxamate, which prevents glycolytic resynthesis of ATP, has been shown to possess a significant, in vitro cytotoxic effect for EB2 cells and for the acute leukaemia lymphoblast. This result was obtained at an oxamate concentration of 0.08 M in TC 199 medium adjusted to physiological osmolality, in comparison with control cultures containing an equimolar concentration of sodium chloride. No significant oxamate cytotoxicity was found for normal marrow myeloid precursors or for blood lymphocytes and neutrophils, although a significant reduction in glycolysis‐dependent neutrophil phagocytosis was obtained.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
