Abstract
AbstractA 1‐year‐old, entire, crossbred, female dog examined for apathy, lethargy, unilateral nosebleed of 2‐month duration and the presence of symmetrical ulcerative dermatitis (small ulcers covered by a haemorrhagic crust and surrounded by alopecia on the tip of the ear pinna). Laboratory alterations included anaemia and hyperglobulinemia with a presumptive polyclonal spike in the beta fraction. High antibody levels to Leishmania infantum were detected by enzyme‐linked immunosorbent assay. An anti‐Leishmania therapeutic protocol was established and a reduction of the anti‐Leishmania antibodies was detected by an end point sera dilution enzyme‐linked immunosorbent assay during the first weeks of therapeutic protocol, while C‐reactive protein concentration was reduced during the period of time when meglumine antimoniate was administered. A good clinical response to the treatment was detected after initiating the anti‐Leishmania treatment. Quantitative serology is useful in the short‐term, because using a two‐fold serial dilution technique correlates with the clinical response.
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