Selective Functionalizations of Cycloalkene‐Fused β‐Lactams and their Transformations into Densely‐Substituted Three‐Dimensional Molecular Entities

Abstract

AbstractHighly‐functionalized, three‐dimensional molecules have had an increasing impact in synthetic organic chemistry and pharmaceutical research over the past decades. Their syntheses and the development of novel synthetic approaches towards versatile, small molecules with chemical and structural diversity have generated great interest. We have designed various selective and stereocontrolled methodologies for the functionalization of cycloalkene‐fused β‐lactams with a common C−C bond, as three‐dimensional, functionalized scaffolds, involving the transformation of their ring olefin bond. The synthetic methodologies developed to access various pharmacologically interesting derivatives with multiple chiral centers might be valuable protocols for the preparation of other classes of organic compounds as well.