Abstract
Abstract As a model for prebiotic sugar formation under neutral to acidic conditions, reactions of formaldehyde over hydrotalcite-type catalysts were investigated. Heating an aqueous solution of formaldehyde at 140—200 °C for 12 h over Ni–Fe hydrotalcite-type catalyst afforded 2-hydroxy-3,3-bis(hydroxymethyl)-γ-butyrolactone selectively, a 5.8% yield based on gas–liquid chromatographic analysis. The structure was identified by 1H and 13C NMR and 1H–13C HSQC, HMBC and 13C–13C 2D INADEQUATE NMR experiments.
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