Abstract
Intermittent electrical stimulation of the perforant path (PPS) for 24 h in anesthetized rats results in impairment of paired pulse inhibition, neuronal loss in the dentate gyrus and hippocampus, and delayed spontaneous seizures. One week after PPS, animals showed a dramatic decrease in afterdischarge threshold and increase in afterdischarge duration from the basolateral amygdala, whereas no changes in afterdischarge properties were observed from the dentate gyrus. Animals also showed a remarkable facilitation of amygdala kindling, but not of perforant path kindling. After amygdala kindling, some animals showed spontaneous seizures. PPS may recruit amygdala into the epileptogenic circuit, resulting in `latent' kindling and development of spontaneous seizures.
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