Selective Extraction of G‐Quadruplex Ligands from a Rationally Designed Scaffold‐Based Dynamic Combinatorial Library

Abstract

Fishing for ligands: The power of dynamic combinatorial chemistry in drug discovery is boosted by a design principle allowing multiple scaffold substituents. Library analysis is furthermore assisted by taking advantage of the UV/Vis spectra of the scaffolds, and an active compound is extracted from the mixture with high selectivity over less active compounds (see figure).