Abstract
Denise Börzsei1, Renáta Szabó1,2, Alexandra Hoffmann1, Krisztina Kupai1, Anikó Magyariné Berkó1, Csaba Varga1 and Anikó Pósa1,2* Author Affiliations 1Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, Hungary 2Department of Physiology, Anatomy and Neuroscience, Interdisciplinary Excellence Centre, Hungary Received: April 08, 2019 | Published: April 18, 2019 Corresponding author: Anikó Pósa, Department of Physiology, Anatomy and Neuroscience, Szeged, Hungary DOI: 10.26717/BJSTR.2019.17.002969
Highlights
The average life expectancy is increasing worldwide women spend more than one- third of their lives in estrogen deficiency
Our findings show that E2 and RAL have an important role in the regulation of arginine vasopressin (AVP) level
Our findings are in accordance with a previous study that proved the increasing activity of AVP neurons in postmenopausal women [7]
Summary
The average life expectancy is increasing worldwide women spend more than one- third of their lives in estrogen deficiency. Several studies confirmed that cardiovascular diseases appear more likely in women over 60 years old than age-matched men [1]. It is proved that middle-aged women who receive hormone replacement less likely to suffer from circulatory disorders. Large number of animal studies confirmed the protective effects of estrogen replacement, human clinical researches were inconclusive. Long term hormone administration increases the chance of breast and endometrial carcinoma development [2]. Selective estrogen receptor modulators (SERM) are a class of drugs that have estrogen agonist characteristics in target tissues such as cardiovascular system or central nervous system, they are not oncogenic [3]
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