Abstract
This work demonstrates that exposure of cells to a poly(ethylene oxide)-poly(propylene oxide) block copolymer, Pluronic P85, results in substantial decrease in ATP levels selectively in MDR cells. Cells expressing high levels of P-glycoprotein are highly responsive to the Pluronic treatment, while those with low levels of expression are much less responsive. Cytotoxicity studies suggest that Pluronic acts as a chemosensitizer and potentiates cytotoxic effects of doxorubicin in MDR cells. Because many mechanisms of drug resistance are energy-dependent, a successful strategy for treating MDR cancer could be based on selective energy depletion in MDR cells. Therefore, the finding of energy-depleting effects of Pluronic P85, in combination with its sensitization effects is of considerable theoretical and practical significance.
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