Abstract
Hydrogen sulfide (H2S) is known to be an important mediator of diverse cellular functions in health and in disease. It is of great importance to develop a selective and efficient detection method for H2S. Herein, we report an iridium-based electrochemiluminescent (ECL) sulfide probe (1) composed of the acrylate and dinitrobenzenesulfonyl (DNBS) units as both reactive and quenching groups. While control probes (2 and 3) having either acrylate or a DNBS group exhibited moderate selectivity for sulfide and other biothiols, the dual-quenching chemodosimetric ECL probe 1 installed with both acrylate and DNBS units enabled selective sensing of sulfide anions over various anions and biothiols with high turn-on ratio. The sensing mechanism of probe 1 was elucidated using MALDI-TOF mass and 1H NMR analyses. Probe 1 was successfully applied to the detection of H2S in human serum by the ECL method. This ECL-based detection method can be developed into a point-of-care testing method for selective sensing of sulfide.
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