Year-end Sale % OFF 
Abstract
The effects of methylglyoxal-bis(guanylhydrazone) on selected cellular immune functions and on S-adenosylmethionine decarboxylase activity were studied in spleen cells from mice given sublethal doses of this drug. The development of antibody-forming cells was markedly inhibited after administration of methylglyoxal-bis(guanylhydrazone) whereas the functions of cytotoxic effector cells and phagocytes were not affected. The activity of S-adenosylmethionine decarboxylase was found to be greatly increased in spleen cells from mice given the drug, and this increase was 4- to 5-fold greater in nylon wool-adherent cell populations as compared to that in non-adherent cell populations. The uptake of methylglyoxal-bis(guanylhydrazone) was 1.5- to 2-fold greater in nylon wool-adherent cells than in non-adherent cells. These studies suggest that methylglyoxal-bis(guanylhydrazone) selectively affects antibody-forming cells among mouse spleen cell populations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
