Abstract
Publisher Summary This chapter describes the selective depletion of brain regional noradrenaline by systemic 6-hydroxydopamine in new born rats. Administration of 6-hydroxydopamine systemically to newborn rats causes not only a permanent destruction of the peripheral adrenergic nervous system, but also a prolonged depletion of noradrenaline from various regions of the central nervous system. In subsequent experiments one found that by restricting the period of intraperitoneal administration of 6-hydroxydopamine to one, or two days during the first 12 days after birth it was possible to deplete the noradrenaline in various brain regions selectively. Injection on days 1, and 2 after birth caused a depletion of noradrenaline in the cerebral cortex, hippocampus and spinal cord, whereas injection on days 9, and 10 after birth caused predominantly a depletion of cerebellar noradrenaline. Noradrenaline levels in the thalamus, and hypothalamus, and dopamine levels in the striate regions were not affected, and noradrenaline levels in the pons-medulla were increased, particularly following treatment on days 1, and 2.
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