Abstract

The synthesis of a novel copper (II) complex, namely, [Cu(phen)(NO2-impi)]2+ (where phen is 1,10-phenanthroline; NO2-impi is 2-(2-(4-nitrophenyl)-5-(pyridin-2-yl)-1H-imidazol-4-yl) pyridine, ZU-3, was performed. UV titration and viscosity measurements were used to determine its interaction with ds-DNA. The binding constant of complex to ds-DNA was 1.3x105 M-1. The Stern-Volmer extinction constant (KSV) for ZU-3 was calculated as 1.2 x 105 M-1. The complex was screened against five human cell lines, namely A 549, PC-3, BEAS-2B, HCT-116 and MDZMB-231, and it was found that ZU-3 shows selective cytotoxicity on colon cancer cells. It has been found that ZU-3 reduced HCT-116 cell density and caused pyknotic morphology that are associated with cell death by apoptosis.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.