Abstract
Ovarian clear cell carcinoma (CCC) is a histological type of epithelial ovarian cancer that is less responsive to chemotherapy and associated with a poorer prognosis than serous and endometrioid carcinoma. Non-thermal atmospheric pressure plasma which produces reactive species has recently led to an explosion of research in plasma medicine. Plasma treatment can be applied to cancer treatment to induce apoptosis and tumor growth arrest. Furthermore, recent studies have shown that a medium exposed to plasma also has an anti-proliferative effect against cancer in the absence of direct exposure to plasma. In this study, we confirmed whether this indirect plasma has an anti-tumor effect against CCC, and investigated whether this efficacy is selective for cancer cells. Non-thermal atmospheric pressure plasma induced apoptosis in CCC cells, while human peritoneal mesothelial cells remained viable. Non-thermal atmospheric pressure plasma exhibits selective cytotoxicity against CCC cells which are resistant to chemotherapy.
Highlights
Epithelial ovarian carcinoma (EOC) is the most frequent cause of gynecological cancer-related death in women in Western countries
In this study, using indirect plasma in the form of nonequilibrium atmospheric pressure plasma (NEAPP), which is a type of non-thermal atmospheric pressure plasma, we demonstrated selective cytotoxicity against cell carcinoma (CCC) cells, which are less sensitive to chemotherapy compared to normal cells
The viability decreased by approximately 61% when cells were treated with NEAPP-AM-5, and 87% after being treated with NEAPP-AM-8 compared to non-NEAPPexposed medium treatment (P
Summary
Epithelial ovarian carcinoma (EOC) is the most frequent cause of gynecological cancer-related death in women in Western countries. Ovarian clear-cell carcinoma (CCC), a subtype of EOC, is relatively less sensitive to chemotherapy, and is recognized as refractory ovarian cancer (Kajiyama et al 2012). Various additional molecular-targeting therapies, including antiangiogenic agents and cancer vaccine treatment, have. It had been demonstrated that plasma can induce apoptosis in cancerous cells (Fridman et al 2007; Keidar et al 2011; Kim et al 2010a; Kalghatgi et al 2011), and it is expected to provide an alternative for cancer treatment. Some researchers have reported the therapeutic potential of the selective cytotoxicity of plasma (Keidar et al 2011; Kim et al 2009; Tanaka et al 2011). We confirmed the selectivity of plasma against EOC (Iseki et al 2012; Utsumi et al 2013)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
