Abstract
In this study, agomelatine Form I was selectively recrystallized from molten state induced by ethyl cellulose (EC). It was found EC could effectively inhibit the transformation process of Form I to Form II. The effect of EC on the recrystallization of agomelatine from molten state was studied in detail. Simultaneous X-ray powder diffraction (PXRD), differential scanning calorimetry (DSC), and polarized light microscopy (PLM) were used to investigate its thermodynamic performance. In addition, the stability and solubility of the Form I induced by EC were carefully explored indicating it gained more stability compared with other forms produced without EC.
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