Abstract
Acute treatment with morphine sulfate produces a selective loss of calcium from synaptosomal particulate fractions of rat brain. No changes in sodium, potassium or magnesium content were observed for myelin, synaptosomal particulate or mitochondrial fractions. Acute opiate treatment (90 min.) while causing calcium loss, produced no changes in regional brain content for sodium, potassium or magnesium. Naloxone, in the presence of morphine, reversed the calcium loss in both regional brain areas and synaptosomal particulate fractions. An hypothesis is offered that naloxone may bind to synaptosomal membranes protecting a morphine sensitive calcium pool, or may reverse the calcium loss seen after opiate agonist treatment.
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