Abstract
Ruthenium complexes are well known for their high affinity and reactivity with DNA. There are so many reports about the interactions of ruthenium complexes and duplex DNA. However, their effects on other DNA structures are poorly studied. In this paper, the photo-activated DNA cleavage by two ruthenium(II) complexes was researched. It was found that these complexes can selectively act on the guanosine bases located in DNA non-duplex portions which were contained in the well matched duplex structures. The mechanism was also studied and considered to be a singlet oxygen oxidation. Through the molecular modeling experiment, we proposed that the strong interaction of complexes with non-duplex DNA structure cause the structural selectivity of DNA cleavage. The research show great future prospects of these ruthenium complexes to be used in anticancer drug development and nucleic acid structure research.
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