Selective C–Si Bond Formation through C–H Functionalization

Abstract

Silylation of hydrocarbons is one of the most important transformations due to the diverse application of organosilanes. Continuous progress is being made in organosilane synthesis particularly through direct C–H activation/functionalization. This minireview compiles various processes reported for C–Si bond formation from 2000–2014, through C–H activation/functionalization (proximal and remote) and metal-free approaches. 1 Introduction 2 C–Si Bond Formation through C–H Activation in Intermolecular Fashion 2.1 C–Si Bond Formation through Direct C(sp2)–H Activation 2.2 C–Si Bond Formation through Directing Group Assisted C(sp2)–H Activation 2.3 C–Si Bond Formation through sp3 C–H Activation 3 C–Si Bond Formation through Proximal C–H Activation/Functionalization in Intramolecular Fashion 3.1 Intramolecular C–Si Bond Formation through C(sp2)–H Activation 3.2 Intramolecular C–Si Bond Formation through C(sp3)–H Activation 4 Siloles Synthesis through Heteroannulation 5 C–Si Bond Formation through Remote C–H Activation 6 C–Si Bond Formation through C–O Bond Cleavage 7 Metal-Free Methods for C–Si Bond Formation 8 Summary and Outlook