Abstract
Objective To investigate the effect of selective bowel decontamination (SBD) on prognosis of 90% hepatectomy in rats. Methods We adopted rat model of subtotal hepatectomy(90%, SHx), gentamicin + polymyxin + nystatinor saline of the same amount was administrated preoperatively. Liver damage makers, portal and systemic lipopolysaccharide(LPS), mucosal damage, signaling pathways and liver regeneration were investigated. Results We found that SHx resulted in significantly enhancedsystemic LPS. Inhibition of gastrointestinal gram-negative bacteria by SBD significantly reduced LPS levels and improved survival after SHx. SBD protected intestinal mucosa barrier, alleviated liver parenchymal damage and inflammation and promoted liver regeneration. Conclusion SBD is beneficial and necessary for extended heptactomy. Key words: Selective bowel decontamination; Endotoxin; Extended hepatectomy; Liver regeneration; Prognosis; Rat
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