Abstract
Antimalarial activity of tetrandrine was studied using a continuous in vitro culture of Plasmodium falciparum . Experimental results showed that tetrandrine has potent antimalarial effect on both chloroquine sensitive and resistant strains of Plasmodium falciparum . Interestingly, tetrandrine is about three times more potent against the chloroquine resistant strain than it is against the sensitive strain based on their IC 50 values, which were 5.09 × 10 −7 M for the sensitive strain and 1.51 × 10 −7 M for the resistant strain. In addition, reversal experiments revealed that tetrandrine cannot reverse chloroquine-resistance, although it nas verapamil-like, calcium-channel-blocker activity.
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