Abstract
A molecularly imprinted polymer modified carbon paste electrode for determination of methocarbamol drug was constructed and used in aqueous and biological samples. The MIP was synthesized by methacrylic acid as monomer, azobis isobutyronitrile as initiator and methocarbamol as analyte with precipitation polymerization process. The oxidation voltamograms of analyte using MIP modified nickel ferrite catalyst electrode with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) by potentiostat – galvanostat device were obtained. The methocarbamol drug has amine groups in its structure, thus it is affected by the medium pH, and the effect of this factor on the electrode response was investigated. In optimum conditions, 4% MIP, 8% nanoparticles catalyst, and pH 3, 1.0×10-5M standard solution of methocarbamol was prepared and studied by DPV and CV mode. The dynamic calibration ranges, 3.0×10-8 - 3.0×10-6 M, detection limit of the method 1.3×10-8 M and RSD of the method for two measurements 3.33% and 1.00% was obtained.
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