Selective and CO-Retentive Addition Reactions of Acid Chlorides to Terminal Alkynes in Synthesis of β-Chloro-α,β-unsaturated Ketones Using ZnO

Abstract

Abstract The addition reaction of acid chlorides with terminal alkynes to afford β-chloro-α,β-unsaturated ketones using ZnO as catalyst has been studied under solvent-free conditions. All the reactions were done at room temperature and β-chloro-α,β-unsaturated ketones were obtained with selectivity in high yields.