Abstract
Abstract Aliphatic polyamines (putrescin, spermidine, spermine and cadaverine) play an important role in the induction of neoplastic processes leading to cell malignancy. In malignantly transformed cells, a high level of aliphatic polyamines has been observed, which ensures their steady anaplastic growth. This is precisely why elevated levels of the aforementioned polyamines are considered as diagnostic and prognostic criteria for a wide range of oncological diseases. In several developed countries, cancer patients are advised to follow a low-polyamine diet, including specifically those food products that are identified in the general nutrient registry as having low levels of aliphatic polyamines. However, when recommending such a diet, many researchers did not pay attention to the fact that in different food products, the ratio of polyamine levels often varies within very wide limits. Therefore, as some researchers report a polyamine-deficient diet prescribed to cancer patients is not always effective. We analyzed various literary sources and identified products that do not contain polyamines or contain them in very low quantities. Based on the analysis of available literary data, when patients are admitted to oncology clinics, along with generally accepted laboratory diagnostic criteria, it is necessary to include diagnostic indicators for determining the levels of aliphatic polyamines in erythrocytes and blood plasma, including putrescine, spermidine, spermine, and cadaverine. Due to this approach, oncologists and nutritionists may have a real opportunity to prescribe a selective polyamine-deficient diet. For patients with advanced cancer, we recommend the use of a polyamine-free diet instead of a polyamine-deficient one.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.