Selective action of D-penicillamine on guinea pig peritoneal macrophage Fc γ receptors for homologous, monomeric IgG 1

Abstract

Guinea pig oil-induced peritoneal exudates were pretreated with D-penicillamine. The binding of homologous, monomeric IgG 2 and IgG 1 to normal and pretreated exudates was examined. Whereas the 7S IgG 2-IgG 2 Fc γ receptor interaction remains unaffected by the pretreatment, the binding of IgG 1 to the IgG Fc γ receptor population was affected. The significance of the selective effect of D-penicillamine is discussed.