Abstract

Selective acetolysis of the primary benzyloxy groups in a wide variety of carbohydrate derivatives was achieved in excellent yield using acetic anhydride and perchloric acid supported over silica (HClO4–SiO2) as a solid acid catalyst in a fast reaction condition without using any organic solvent. The reaction condition is significantly rapid and can be scaled up for its use in the multi-step oligosaccharide synthesis.

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