Abstract
The membrane theory maintains that the high K+ level inside a cell is dependent on a functioning Na/K pump and that the cell K is dissolved in the cell water. On the other hand, the association-induction hypothesis (AIH) maintains that the bulk of cell K+ is selectively adsorbed to fixed anions of cell proteins.1 Recent experimental findings strongly support this hypothesis: a) An effectively membrane-pumpless open-ended cell preparation continues to demonstrate K+ accumulation and Na+ exclusion much as a normal cell does.2 Independent measurements confirm the prediction of the AIH that cellular K+ (Rb+, Cs+) accumulation occurs at proteins carrying much β-and γ-carboxyl groups (myosin).3,4
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