Abstract
AbstractSince deuterated compounds have significant applications in pharmaceutical chemistry, selective incorporation of deuterium atoms onto a pharmacophore containing compounds has attracted great attention. Herein, we describe a concise method for construction of deuterated dibenzo‐fused ϵ‐lactones and ϵ‐lactams via Pd‐catalyzed carbene bridging C−D bond activation strategy. Readily available deuterated ortho‐bromobenzaldehydes were employed as reactants, and deuterium atom was selectively incorporated at the dibenylic position with high deuterated ratio.
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