Abstract
Recent studies have provided evidence that activation of 5-HT 1A receptors increases epileptic activity in the WAG/Rij rat model of absence epilepsy, and additional data have suggested the involvement of 5-HT 7 receptors as well. Therefore, we have tested the effects of the selective 5-HT 1A receptor antagonist WAY-100635 and the selective 5-HT 7 receptor antagonist SB-258719 on spontaneous epileptic activity. In general, both compounds reduced epileptic activity compared to vehicle. Significant decreases were found in the number of paroxysms and the cumulative and average duration of spike–wave discharges (SWDs), although the time courses of these effects induced by the two compounds were clearly different. These results provide evidence that activation of 5-HT 1A and 5-HT 7 receptors plays a significant role in regulating SWD activity in this animal model of absence epilepsy.
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