Selection of PPI in a comorbid patient with NSAIDgastroesophagopathy: case study

Abstract

Over the past decades, there have been significant changes in the structure of adult morbidity. Clinicians are increasingly faced with the problems of combined pathology and development of comorbidity, as well as to solve the issues of rational tactics of management of such patients. Polypragmasia due to comorbidity leads to a sharp increase in the probability of developing systemic and undesirable effects of drugs, while prolonged use of several drugs can lead to the development of complications that develop into independent nosological forms, which is especially important in older age groups. The most common forms of comorbidity in the elderly are in one or another combination of the following diseases: hypertension, coronary heart disease, diabetes, diseases of the musculoskeletal system. It is known that the leading place in the relief of pain in the latter is occupied by non-steroidal antiinflammatory drugs (NSAIDs), the use of which can be prolonged and induce the development of serious gastrotoxic reactions. Well studied and described NSAIDs-induced gastropathy, which, in most cases, is asymptomatic even in the presence of erosive and ulcerative changes. However, NSAIDs may be associated with the emergence of various dyspeptic complaints and lesions of the esophagus, which can be viewed in the framework of NSAID-associated esophageal, especially relevant in older patients. The article deals with the problem of comorbidity, polypragmasia, therapeutic tactics in the management of comorbid patients with NSAIDsesophagogastropathy and the possibility of prescribing for the prevention and treatment of not only effective, but also safe means of correction of these clinical and endoscopic manifestations.