Abstract

Abstract Ionization and extraction constants for dextromethorphan and 14 other alkoids are given. By constructing the logarithmic distribution diagrams for mixtures of these compounds, Celite partition chromatographic systems can easily be selected for their separation; both free base and ionpair extraction provide useful systems. A general procedure for the isolation of dextromethorphan from any of those alkoids with which it is currently formulated is presented; the results of analyses of standard samples and of commercial sirups are given. Some other separations do not appear to be feasible. However, the distribution diagrams clearly show the reasons for this fact

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