Abstract
An important characteristic of oral medicines, which include medicated chewing gums, is their pleasant taste. This can be achieved by adding taste coregents to their composition. The aim: to choose rational flavour additives and justify the method of their introduction to the compressed medicated chewing gums that are being developed. Materials and methods: mint (Natural Mint Flavor SD, Kerry Inc., Malaysia), apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia) and banana (Banana FLV, Kerry Inc., Malaysia) have been used as powdered flavour additives. As flavourings – oil solutions: Peppermint Natural WonfFlavor, Kerry Inc., Malaysia), Apple (Nat Apple FlavorWonf, Kerry Inc., Malaysia), Strawberry (Strawberry FlavorWonf, Kerry Inc., Malaysia), Melon (Chemical-Food Aromatic PlantLLC, Russian Federation) and Lemon (Chemical-Food Aromatic Plant LLC, Russian Federation). Aerosil brand 380 (Evonik Resource Efficiency GmbH, Germany), Syloid® 244FP (Grace Discovery Sciences, USA) and Neusilin® ULP 2 (Fuji Chemical Industry Co. Ltd, Japan) have been taken as carriers. The choice of flavour additives and flavourings was made using organoleptic methods of coregents evaluation according to A. I. Tentsova and I. A.Yegorov. The technological and physicochemical properties of the samples were studied according to conventional methods of the State Pharmacopoeia of Ukraine. Results and discussion. In determining the taste of medicated chewing gums samples with different coregents, the combination of powder additive and liquid flavouring "Apple" has got the highest mark. In order to substantiate the rational method of liquid flavouring introduction in the composition of the compressed chewing gums, it is proposed to introduce the adsorbents Aerosil 380, Syloid® 244FP and Neusilin® ULP 2, which also play the role of moisture regulators and glidants. Microscopic analysis of adsorbents mixtures with flavouring, as well as physicochemical and technological investigations of the mass for pressing have revealed that the best adsorbing, moisture-regulating and flow properties has Syloid® 244FP. Conclusions. As a coregent in medicated chewing gums was selected a combination of powdered (2.0 %) and liquid (0.6 %) flavours “Apple”. The method of introducing the oil flavouring into the composition of the compressed gums has been chosen – by spraying on the adsorbent with subsequent mixing. Based on the studies, Syloid®244FP at a concentration of 1.0 % was chosen as the rational carrier.
Highlights
During the development of drugs for oral use, great attention is paid to their taste characteristics
(2020), «EUREKA: Health Sciences» Number 2 selection of a rational carrier of oil flavouring in the developed compressed medicated chewing gum (MCG), we have studied the main technological properties of the mass for pressing with the inclusion of these substances at a concentration of 1.0 %
According to the results of determining the taste of MCG samples (Table 2), it has been found that the sample with the combination of powdered flavour additives and liquid flavouring “Apple” has got the highest mark, which became the basis for the choice of these flavours in the composition of MCGs under development
Summary
During the development of drugs for oral use, great attention is paid to their taste characteristics. Dosage forms (DF) of that type of drugs include medicated chewing gum (MCG), the release of APIs from which occurs in the mouth in the process of chewing. It is known that the organoleptic properties of drugs are perceived by man comprehensively and represent a combination of taste and smell [3]. Sweeteners and flavour additives are referred to corrective substances – they mask the unpleasant smell of APIs or complement the sweetener taste [4, 5]. Sweeteners and flavours are listed in foreign pharmacopoeias – European, British and National formulary of USA Pharmacopoeia [6, 7]. These groups of substances are described in DSTU-H CODEX STAN 192: 2014 Nutritional Supplements. Nomenclature and general requirements [8]
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