Abstract
ObjectiveTo choose typical or atypical antipsychotic drugs for treatment of schizophrenic patients in a psychiatric hospital. MethodA standard method was used; this method considers 4 main evaluation criteria and 4 secondary criteria. The typical antipsychotic drug, perphenazine, was compared with the atypical antipsychotic drugs (olanzapine, quetiapine, risperidone, and ziprasidone). The measures of efficacy of the most important criteria come from the clinical trial “Clinical Antipsychotic Trials for Intervention Effectiveness” (CATIE). ResultsThe scores of the different antipsychotic drugs were as follows: perphenazine, 59.68; olanzapine, 52.98; risperidone, 51.53; ziprasidone, 46.42; and quetiapine, 45.41. Olanzapine was equal to perphenazine when the cost criteria was reduced by 72.97%. ConclusionsThe typical antipsychotic drug perphenazine is the drug receiving the best assessment for the treatment of schizophrenia. Olanzapine is an alternative if its cost is reduced.
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