Abstract
Recent advances in cluster synthesis make it possible to produce an enormous variety molecule-like MPCs of size, composition, shape, and surface-chemical combinations. In contrast to the significant growth in the synthetic capability to generate these materials, progress in establishing the physicochemical basis for their observed properties has remained limited. The main reason for this has been the lack of the analytical capability to generate and measure samples of suitably high (molecular) purity; such capability is also essential to support therapeutic and diagnostic MPC development. In order for MPC products to get to market, especially those products that are medical-field related, characterization is required to identify and quantify all components present in a material mixture. Here, we show results from analysis of several synthetic mixtures of gold MPCs by nonaqueous reversed-phase chromatography coupled with mass spectrometry detection. The additional or hidden components, revealed to be present in these mixtures, provide novel insights into their comparative stability and interactions.
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