Abstract
In this article we propose a procedure for selecting a random size subset that contains all experimental treatments that are better than the standard. The comparison is made with regard to two binary endpoints. An experimental treatment is considered to be better than the standard if its two endpoints have successful rates higher than standard rates. We assume responses from different treatments are independent, however, responses from each treatment may be associated. We use the odds ratio as the association parameter and describe the bivariate binomial distribution involved in the computation of the probability of a correct selection for our procedure. We derive the design parameters for three different cases: independent endpoints, dependent endpoints with known association and dependent endpoints with unknown association, and provide tables including the minimum sample size needed for the probability requirements to be satisfied.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
