Abstract
Random base-pairing interactions between messenger RNAs and noncoding RNAs can reduce translation efficiency.
Highlights
Related research article Umu SU, Poole AM, Dobson RCJ, Gardner PP. 2016
Translation is the process by which the genetic information in a molecule of messenger RNA produces a protein, and the rate at which protein is produced from a given mRNA molecule is called the translation efficiency
This number is different for different mRNA molecules (Maier et al, 2009; Guo et al, 2008), which is why researchers are trying to determine which features of these molecules affect their translation efficiency (Tuller et al, 2010; Ferreira et al, 2013; Kozak, 2005; Gingold and Pilpel, 2011)
Summary
Avoidance is the degree to which an mRNA molecule avoids random interactions with noncoding RNA molecules in the cell. The researchers show that the levels of noncoding RNAs in bacterial cells are two orders of magnitude greater than the levels of mRNAs. To estimate the probability of random basepairing interactions taking place between mRNAs and noncoding RNAs, consider a fivebase region in a single mRNA. Given the number of mRNAs and noncoding RNAs that are found in cells, random interactions between the two are inevitable.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
