Abstract
An unprecedented Domino transformation towards diverse fluorinated spiro benzothiazinyl furanone scaffolds has been developed from 1,3‐diketone embedded benzothiazines and Selectfluor through fluorinative intramolecular cyclization. The transformation is triggered by fluorine insertion to form a difluoro intermediate, which is responsible for the formation of fluorinated spiro 3(2H)‐furanone derivatives. We have also succeeded to synthesize non‐fluorinated spiro 3(2H)‐furanone derivatives by oxidative cyclization using AgF.
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