Selected Articles from This Issue

Abstract

Highlights| October 14 2022 Selected Articles from This Issue Author & Article Information Online ISSN: 1557-3265 Print ISSN: 1078-0432 ©2022 American Association for Cancer Research2022American Association for Cancer Research Clin Cancer Res (2022) 28 (20): 4355. https://doi.org/10.1158/1078-0432.CCR-28-20-HI Related Content A commentary has been published: CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization A commentary has been published: EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma A commentary has been published: Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers View more A commentary has been published: Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing View less Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record October 14 2022 Citation Selected Articles from This Issue. Clin Cancer Res 15 October 2022; 28 (20): 4355. https://doi.org/10.1158/1078-0432.CCR-28-20-HI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search Metastatic progression of Ewing sarcoma requires that activity of its oncogenic driver, EWS::FLI1, be moderated. Apfelbaum and colleagues have identified HOXD13 as a tumor-specific regulator of EWS::FLI1 activity. Transcriptomic and epigenomic studies showed that EWS::FLI1 directly activates HOXD13 and that antagonism between these transcription factors determines mesenchymal cell state. In particular, cells with high HOXD13 activity selectively activated mesenchymal programs that are repressed by EWS::FLI1. These studies demonstrate the importance of cell context-dependent transcription factors as moderators of fusion gene activity and phenotypic cell state. Future studies are indicated to determine if these transcriptionally distinct cell states define metastasis-initiating cells. Human papillomavirus (HPV) causes >5% of cancers worldwide leading to significant morbidity and mortality. To address an unmet need for therapies that uniquely target HPV-driven cancers, Ghosh and colleagues tested the efficacy of 864 drugs and identified Aurora kinase inhibitors as effective in HPV-positive cancers. HPV-positive cells, which have low... You do not currently have access to this content.